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Cowbellist
Picture of Jefiner
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the smallpox vax is effective against monkeypox, so all of us here should be covered (smallpox vax was stopped in 1980).

It is spread by contact, so the bath house link makes a lot of sense.


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Don't pet the fluffy murder cow.
 
Posts: 4085 | Registered: August 15, 2014Reply With QuoteReport This Post
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quote:
Originally posted by Jefiner:
the smallpox vax is effective against monkeypox, so all of us here should be covered (smallpox vax was stopped in 1980).


I don't have a scar so I'm figuring either I wasn't vaccinated for it or it didn't take. But not worried, there are treatments for it.
 
Posts: 1352 | Registered: August 04, 2017Reply With QuoteReport This Post
Diner Gradgrinder
Picture of Ginger Quill
posted Hide Post
quote:
Originally posted by Webster:
quote:
Originally posted by Jefiner:
the smallpox vax is effective against monkeypox, so all of us here should be covered (smallpox vax was stopped in 1980).


I don't have a scar so I'm figuring either I wasn't vaccinated for it or it didn't take. But not worried, there are treatments for it.


Webster, you may have been vaccinated for SP but the scar has disappeared. Mine vanished decades ago. It was sop for many moms to keep "baby books" on everything the child did including immunization records. If your mom is still living ask her if she kept one. Iirc, many of those vaccines were given at school: a notice was pinned to your shirt to take home letting parents know when the shots were being given.
 
Posts: 766 | Registered: August 16, 2014Reply With QuoteReport This Post
Picture of dissimulo
posted Hide Post
quote:
Originally posted by Jefiner:
the smallpox vax is effective against monkeypox, so all of us here should be covered (smallpox vax was stopped in 1980).


Smallpox vaccination was actually stopped in the USA in 1972. You only got it after that if you were in the military or traveled to regions where it was still a problem.
 
Posts: 2789 | Registered: April 13, 2007Reply With QuoteReport This Post
Diner Gradgrinder
Picture of Ginger Quill
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Posts: 766 | Registered: August 16, 2014Reply With QuoteReport This Post
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Malone's substack on monkeypox. He says there is evidence what is out there might be lab manipulated.

https://rwmalonemd.substack.com/p/monkey-pox-update
 
Posts: 1352 | Registered: August 04, 2017Reply With QuoteReport This Post
Picture of dissimulo
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The mutation rate seen so far is not particularly surprising. The difference in mutation rate between RNA and DNA viruses is about two orders of magnitude, but that is still a large number of events when you consider the number of affected cells is in the trillions. If a billion cells are infected, then, for every nucleotide in the virus, you would expect to find about 10 with a mutation. Most of those don't survive or don't reproduce significantly and would never arise to visibility at even high sample sizes, but all it takes is for one to be first in infecting a new cell and suddenly you have a large number of copies. Still, those are only significant if they have a competitive advantage and become a dominant strain, not if they merely exist at some point in time. But when you are talking about virus particles in the trillions per host, low individual odds accumulate dramatically.

It is also probable that we are selecting for viral evolution. Some articles have mentioned that they are trying antivirals on some of the patients. Given the affected group, it would also not be surprising if some of them are on HIV antiretrovirals. Antivirals tend to increase the mutation rate in viruses by breaking the equipment that translates and error corrects DNA.

Anyway, I wouldn't start to worry about the SNP rate unless it reaches about 100 times greater than it is now. Anything up to that point would be pretty much in line with natural variation under an intensive testing regime.
 
Posts: 2789 | Registered: April 13, 2007Reply With QuoteReport This Post
Picture of Mr Breeze
posted Hide Post
quote:
Originally posted by dissimulo:
The mutation rate seen so far is not particularly surprising. The difference in mutation rate between RNA and DNA viruses is about two orders of magnitude, but that is still a large number of events when you consider the number of affected cells is in the trillions. If a billion cells are infected, then, for every nucleotide in the virus, you would expect to find about 10 with a mutation. Most of those don't survive or don't reproduce significantly and would never arise to visibility at even high sample sizes, but all it takes is for one to be first in infecting a new cell and suddenly you have a large number of copies. Still, those are only significant if they have a competitive advantage and become a dominant strain, not if they merely exist at some point in time. But when you are talking about virus particles in the trillions per host, low individual odds accumulate dramatically.

It is also probable that we are selecting for viral evolution. Some articles have mentioned that they are trying antivirals on some of the patients. Given the affected group, it would also not be surprising if some of them are on HIV antiretrovirals. Antivirals tend to increase the mutation rate in viruses by breaking the equipment that translates and error corrects DNA.

Anyway, I wouldn't start to worry about the SNP rate unless it reaches about 100 times greater than it is now. Anything up to that point would be pretty much in line with natural variation under an intensive testing regime.


Thank You


---------------------------
Call me the Breeze -------
 
Posts: 965 | Registered: December 04, 2015Reply With QuoteReport This Post
Cowbellist
Picture of Jefiner
posted Hide Post
quote:
Originally posted by dissimulo:
The mutation rate seen so far is not particularly surprising. The difference in mutation rate between RNA and DNA viruses is about two orders of magnitude, but that is still a large number of events when you consider the number of affected cells is in the trillions. If a billion cells are infected, then, for every nucleotide in the virus, you would expect to find about 10 with a mutation. Most of those don't survive or don't reproduce significantly and would never arise to visibility at even high sample sizes, but all it takes is for one to be first in infecting a new cell and suddenly you have a large number of copies. Still, those are only significant if they have a competitive advantage and become a dominant strain, not if they merely exist at some point in time. But when you are talking about virus particles in the trillions per host, low individual odds accumulate dramatically.

It is also probable that we are selecting for viral evolution. Some articles have mentioned that they are trying antivirals on some of the patients. Given the affected group, it would also not be surprising if some of them are on HIV antiretrovirals. Antivirals tend to increase the mutation rate in viruses by breaking the equipment that translates and error corrects DNA.

Anyway, I wouldn't start to worry about the SNP rate unless it reaches about 100 times greater than it is now. Anything up to that point would be pretty much in line with natural variation under an intensive testing regime.
Thumbs Up


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Posts: 4085 | Registered: August 15, 2014Reply With QuoteReport This Post
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JC's Lies You Can Trust broadcast reports on monkeypox.

https://rumble.com/v16pmna-mon...re-you-with-now.html
 
Posts: 1352 | Registered: August 04, 2017Reply With QuoteReport This Post



Picture of Brutus
posted Hide Post
quote:
Originally posted by dissimulo:
quote:
Originally posted by Jefiner:
the smallpox vax is effective against monkeypox, so all of us here should be covered (smallpox vax was stopped in 1980).


Smallpox vaccination was actually stopped in the USA in 1972. You only got it after that if you were in the military or traveled to regions where it was still a problem.



I must've come in just under the wire on that one.

I was just a wee lad at that time (turned 5 in Dec. of '72), but I definitely have a smallpox vax scar on my upper arm.


Smile


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I am Brutus. Or, Lord Brutus if you prefer.
 
Posts: 2457 | Location: southwest Mississippi | Registered: August 20, 2014Reply With QuoteReport This Post
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